In any MMO I play, I usually end up turning off some of the chat channels. Out of Character is usually the first to go, quickly followed by Looking for Group and anything General, Noob, Level, or Advice related.
Of course, there is a cost. It means I end up missing exchanges like this one from LOTRO about twenty times a night:
[Advice] B***: ‘are there guns in this game?’
[Advice] R*****: ‘…’
[Advice] L*****: ‘Yes… you get shotguns and plasma rifles’
[Advice] V*******: ‘The best you’ll get are the fiery bombs wielded by sapper goblins.’
[Advice] S****: ‘Do you know anything about lotr?’